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KMID : 0614620140640030158
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Korean Journal of Gastroenterology
2014 Volume.64 No. 3 p.158 ~ p.163
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Two Cases of Wernicke’s Encephalopathy That Developed during Total Parenteral Nutrition in Colon Cancer Patients Treated with 5-Fluorouracil-based Chemotherapy
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Cho Kyung-Pyo
Lee Jae-Sung
Seong Ji-Seok
Woo Yong-Moon
Cho Young-Jun
Jeong Beom-Jin
Sohn Jee-Hoon
Kim Su-Jung
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Abstract
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Wernicke’s encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in patients after gastrointestinal surgery and in those with malabsorption. In addition, patients undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), and being treated with chemotherapeutic agents are also prone to develop thiamine deficiency. Herein, we report two cases of WE that developed following simultaneous 5-fluorouracil (5-FU) chemotherapy and TPN in colon cancer patients which was successfully treated with thiamine administration.
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KEYWORD
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Wernicke encephalopathy, Thiamine, Total parenteral nutrition, Fluorouracil, Colonic neoplasms
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